Open Chemistry Journal




ISSN: 1874-8422 ― Volume 6, 2019
RESEARCH ARTICLE

A Non-Ionic Gadolinium Complex whose Relaxometric Behavior is Sensitive to the variation of pH. An Experimental and Theoretical Study on Geometry, Bonding Nature of polyaminocarboxylic Ligand and Their Gadolinium Complex



Eduardo M. Rustoy1, 2, *, Norberto Raggio1
1 UMYMFOR, Departamento de Química Orgánica, FCEyN, CONICET-Universidad de Buenos Aires, Pabellón II, Ciu-dad Universitaria, Ciudad Autónoma de Buenos Aires 1428, Argentina
2 Departamento de Ciencias Básicas, Universidad Nacional de Luján, Ciudad de Luján 6700, Argentina

Abstract

Background:

In addition, the contribution of cyclic structure to the stability of lanthanide complexes has been evaluated on different ligand platforms and some indications of their relative stability are now available. Additionally, it is well known that one of the most important factors to design smart contrast is pH.

Objectives:

The main objectives were to optimize the synthesis of the macrocyclic ligand, using micro-waves. Then study the relaxometric behavior in vitro, depending on the pH, of the gadolinium complex and propose a potential structure-activity relationship of the same.

Methods:

The reactions assisted by microwaves were carried out using a Discover® CoolMate™. Nuclear Magnetic Resonance (NMR) spectra were acquired at 200 and 500 MHz. The Infrared (IR) spectrum of the complex was measured as KBr discs between 400 and 4000cm-1. Electrospray Ionization-High Resolution Mass Spectrometry (ESI-HRMS) was performed on a Bruker microTOF-Q II spectrome-ter. The r1 measurements of the complexes were at 0.2 T, by the inversion recovery method. For the theoretical analysis presented in this work, Hartre- Fock and semiempirical methods were used.

Results:

In the first place, it was possible to carry out the microwave-assisted synthesis of two intermediaries, with higher yields and in a more environmentally friendly way. Then the variation of r1 was checked as a function of the pH value, obtaining a maximum approximately at pH 6.5. The computer tools allowed to propose the possible structures of the coordination compound obtained.

Conclusion:

It was found that the variation of the value of r1 as a function of pH is not a product of the decomposition of the complex, but a stage in which at pH values higher than 7 the complex would undergo a displacement of the water molecule located in the ninth coordination position of the Gd+ 3. This behavior could be due to the replacement of the water molecule by the OH group of the ligand.

Keywords: Gadolinium, Magnetic resonance imaging, Macrocyclic ligand, MOPAC/Sparkle, Longitudinal relaxivity, Infrared.


Article Information


Identifiers and Pagination:

Year: 2018
Volume: 5
First Page: 102
Last Page: 118
Publisher Id: CHEM-5-102
DOI: 10.2174/1874842201805010102

Article History:

Received Date: 25/4/2018
Revision Received Date: 12/6/2018
Acceptance Date: 28/8/2018
Electronic publication date: 30/10/2018
Collection year: 2018

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© 2018 Rustoy and Raggio.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this autor at the UMYMFOR, Departamento de Química Orgánica, FCEyN, CONICET-Universidad de Buenos Aires, Pabe-llón II, Ciudad Universitaria, Ciudad Autónoma de Buenos Aires 1428, Argentina; Tel/Fax: +54-11-4576-3385; E-mail: erustoy@yahoo.com.ar


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