Open Chemistry Journal




ISSN: 1874-8422 ― Volume 6, 2019
RESEARCH ARTICLE

Synthesis, Characterization and Biological Analysis of Some Novel Complexes of Phenyl Thiourea Derivatives with Copper



Neha Mathur1, *, Nisha Jain2, A.K. Sharma3
1 Department of Chemistry, Pt. N.K.S. Govt. P.G. College, Dausa-303303, Rajasthan, India
2 Department of Chemistry, S.S. Jain Subhodh P.G. College Jaipur-302001, Rajasthan, India
3 Department of Chemistry, Govt. P.G. College, Jhalawar-326001, Rajasthan, India

Abstract

Introduction:

Copper is a very important metal because all forms of life require copper metals an essential micronutrient. Various biological processes, directly or indirectly are dependent on copper metal.

Methods:

Copper soaps are used as fungicides, bacteriosides, herbicides and insecticides. Copper complexes including heterocyclic compounds have attracted our attention in a magnificent way because of its utility in catalysis and biological functions. Their mechanism of synthesis, characterization and structural insight, are crucial for comprehending the criteria of the bonding and electronic interactions between the proximate metal center and chelating atoms. But still, there is a need to explore some of more biological properties for their wide applicability and significant usage in multiple fields because it is an untapped area with potentially tremendous value. Hence, in this paper, we report the synthesis and characterization of transition metal complex of N/S ligand by chromatographic, FT-IR, NMR, ESR, elemental analysis, conductometric and magnetic moment measurements.

Results:

The synthesized metal complexes namely copper palmitate with 4-nitrophenylthiourea and copper palmitate with 4-methoxyphenylthiourea were successfully investigated for biological activities against fungi Candida albicans and Trichoderma harzinum. Based on the results, we pronounced biocidal activities of the novel complexes.

Conclusion:

It is concluded that the activity of nitro phenylthiourea complex has greater antifungal activity than methoxy phenylthiourea complex against these test fungi. We can conclude that the antifungal activity of these complexes varies according to the nature of the groups attached to the ligands.

Keywords: p-Substituted phenylthiourea, Kirby-Bauer and Stokes' methods, Copper soaps, Biological activities, Antifungal.


Article Information


Identifiers and Pagination:

Year: 2018
Volume: 5
First Page: 182
Last Page: 195
Publisher Id: CHEM-5-182
DOI: 10.2174/1874842201805010182

Article History:

Received Date: 28/06/2018
Revision Received Date: 02/11/2018
Acceptance Date: 07/11/2018
Electronic publication date: 31/12/2018
Collection year: 2018

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© 2018 Mathur et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Department of Chemistry,Pt. N.K.S. Govt. P.G. College, Dausa-303303, Rajasthan, India, Tel: +91 9414738865; Email:nehavmathur@yahoo.co.in


Endorsements



I am completely satisfied with the service I received from Bentham Science Publishers, right from the submission of our research paper in ‘Open Chemistry’ to its publication in the journal. The reviewers' and editor's comments were very helpful in improving the paper.

I take this opportunity to express my appreciation to the whole team of BSP!


Dr. Arun Kumar Sharma
Govt. P.G. College,
India


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