Clinical Practice & Epidemiology in Mental Health

ISSN: ― Volume ,

Health Related Quality of Life in Patients with Onco-hematological Diseases

Giorgio La Nasa1, Giovanni Caocci1, *, Emanuela Morelli1, Elena Massa2, Antonio Farci2, Laura Deiana2, Elisa Pintus2, Mario Scartozzi2, Federica Sancassiani2
1 Ematologia e CTMO, Ospedale Businco, Azienda Ospedaliera Brotzu, Cagliari, Italy
2 Dipartimento di Scienze Mediche e Sanita Pubblica, Universita di Cagliari, Cagliari, Italy



HRQoL is generally conceptualized as a broad multidimensional construct that refers to patients' perceptions of the impact of disease and its treatment on their physical, psychological, and social functioning and well-being. Little is known in patients with onco-hematological cancer in comparison with the general population and other chronic diseases.


We assessed HRQoL in patients diagnosed with haematological cancers in comparison with the general population and other chronic diseases.


The questionnaire Short Form (SF)-12 was administered to 62 patients with onco-hematological disease and results were compared with 702 controls (184 healthy people, 37 Major Depression, 201 Multiple Sclerosis; 23 Wilson disease; 46 Carotidal Atherosclerosis; 60 Celiac disease; 151 solid tumours).


HRQoL in patients diagnosed with a haematological cancer was significantly worse in comparison with the general population (F= 43.853, p <0.00001) but similar when compared with solid tumour and other chronic diseases such as Major Depression and Carotid Atherosclerosis. In addition, HRQoL in patients diagnosed with a haematological cancer was significantly higher than that due to Celiac disease (p <0.00001) and Wilson's disease (p= 0.02), and lower than that due to Multiple Sclerosis (p= 0.032).


This study confirmed that haematological cancers negatively affects overall HRQoL. The results showed an impact of haematological cancers on HRQoL that is similar to what found in patients with solid tumors, Major Depression and Carotid Atherosclerosis. Current successful therapeutic strategy achieved in the treatment of haematological cancers not only positively impact on survival rate but also could improve the overall HRQoL.

Keywords: HRQoL, Hematological cancer, Mood depression, SF-12, Multiple Sclerosis, Tumors, Celiac disease.

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 16
First Page: 174
Last Page: 179
Publisher Id: CPEMH-16-174
DOI: 10.2174/1745017902016010174

Article History:

Received Date: 10/5/2020
Revision Received Date: 3/6/2020
Acceptance Date: 6/6/2020
Electronic publication date: 30/07/2020
Collection year: 2020

© 2020 La Nasa et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Ematologia e CTMO, Ospedale Businco, Azienda Ospedaliera Brotzu, Via Jenner, sn, 09124 Cagliari, Italy; Tel: +39-70-52964901; Fax: +39-70-52965317; E-mail:

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