The Open Antimicrobial Agents Journal


(Discontinued)

ISSN: 1876-5181 ― Volume 4, 2013

In Vitro Antimicrobial and Antibiofilm Activity of DispersinB®-Triclosan Wound Gel against Chronic Wound-associated Bacteria


The Open Antimicrobial Agents Journal, 2011, 3: 12-16

Purushottam V. Gawande , Nandadeva Yakandawala , Karen LoVetri , Srinivasa Madhyastha

Kane Biotech Inc, 5-1250 Waverley Street, Winnipeg, MB, R3T 6C6, Canada

Electronic publication date 25/8/2011
[DOI: 10.2174/1876518101103010012]

Abstract:

Since the traditional methods of treatment have proven ineffective against chronic wounds involving biofilms, the present study evaluates the in vitro efficacy of a novel wound gel comprising an antibiofilm DispersinB® -enzyme and a broad-spectrum antimicrobial triclosan against chronic wound-associated bacteria. The antimicrobial and antibiofilm activity of DispersinB®-triclosan wound gel was tested against chronic wound-associated bacteria such as Staphylococcus aureus, methicillin-resistant S. aureus (MRSA), Staphylococcus epidermidis, coagulase-negative Staphylococci, Acinetobacter baumannii and Klebsiella pneumoniae using a quantitative culture method and a biofilm assay. The DispersinB®-triclosan wound gel showed more enduring antimicrobial activity against the test organisms compared to commercial wound gels Silver-Sept and IODOSORB. When DispersinB®-triclosan wound gel was tested against preformed biofilm, it showed 2-4 log10 reduction in the biofilm embedded bacterial cells. Furthermore, DispersinB®-triclosan wound gel compared to IODOSORB was significantly more effective in inhibiting biofilm in MRSA and A. baumannii (P < 0.05). This study indicates the potential application of a broad-spectrum DispersinB®-triclosan wound gel with both antibiofilm and antimicrobial activity in biofilm-based chronic wound management.


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