The Open Autoimmunity Journal




(Discontinued)

ISSN: 1876-8946 ― Volume 6, 2014

CD4+CD25+ Regulatory T Cells Preventing Detrimental Autoimmune Reactions


The Open Autoimmunity Journal, 2013, 5: 1-5

Muhaimin Rifa'i

Department of Biology, Faculty of Sciences, Brawijaya University, Jl. Veteran Malang 65145, East Java, Indonesia.

Electronic publication date 20/9/2013
[DOI: 10.2174/1876894601305010001]




Abstract:

Objective:

Autoimmune diseases will occur when the immune response inflicts damage to tissues in the body. Attempts to overcome this disease have a lot to do but they have not yielded satisfying results. In this study, the function of CD4+CD25+ regulatory T cells was evaluated for therapeutic potential to prevent the development of autoreactive T cells.

Methods:

The isolation of CD4+CD25+ regulatory T cells was performed by using FACS vantage. It was conducted by taking a spleen of 6-week-old C57BL/6 mice. Cells having high purity (2x106) were intravenously injected into 3-weekold CD122-/- mice. In this experiment we used congeneic mice as donors and transferred hosts. The result of adoptive transfer was examined after 7 weeks.

Result:

Here we showed that the transfer of CD4+CD25+ regulatory T cells into CD122-/- mice significantly prevented the development of abnormal T cells. The injection of CD4+CD25+ regulatory T cells derived from normal young mice into CD122-/- mice could prevent the development of activated memory T cells and these cells were essential for maintaining normal homeostasis (P >0.01).

Conclusion:

In this study we obtained evidence that regulatory T cells (2x106) derived from normal young mice could overcome diseases when transferred to the mouse models of autoimmune disorder.


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