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In order to know the associations between multifocality (MF), without related multicentricity (MC), and
common clinical and biological parameters, and posterior influence in breast carcinoma behavior, we have developed this
study. 816 successive women affected from invasive breast carcinomas, of which 96 were multifocal and 720 nonmultifocal
were included in the study. We considered age, size, lymph node involvement, distant metastasis, histological
grade, ploidy, cellular synthesis phase, as well as expression of estrogen receptor (ER), progesterone receptor (PgR),
androgen receptor (AR), p53, bcl2 and Ki67 by immunohistochemical assays.
Taken as a whole, multifocal invasive carcinomas (11%) showed exclusively more distant metastasis and more tumorrelated-
deaths. However, when tumors were classified according to histological type, in ductal carcinomas MF courses
exclusively with greater lymph node involvement, while in non ductal carcinomas MF showed higher percentage of
distant metastasis, higher proliferation and higher number of recurrences. Also, there were NO differences between
axillary lymph node involvement and tumor size in multifocal tumors regardless of histology.
Our results suggest: 1) MF was found in 11% of invasive breast carcinomas and was associated with higher distant
metastasis and number of tumor-related-deaths. 2) in invasive ductal carcinomas, MF was associated, exclusively, with
increased axillary node involvement, whereas in other histological types, with a predominance of lobular, it did with
higher distant metastasis, cell proliferation and recurrence number, suggesting, in this subtype of tumors where there is
higher prognostic/diagnostic value has the MF presence.