The Open Bioactive Compounds Journal




ISSN: 1874-8473 ― Volume 7, 2019

Methyl Ganoderic Acid DM: A Selective Potent Osteoclastogenesis Inhibitor



Jie Liu1, Jun Shiono1, Yukiko Tsuji2, Kuniyoshi Shimizu1, *, Ryuichiro Kondo1
1 Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan
2 Bio-Architecture Center, Kyushu University, Fukuoka, 812-8581, Japan

Abstract

Increased osteoclastic bone resorption plays a central role in the pathogenesis of many bone diseases, and osteoclast inhibitors are the most widely used treatments for these diseases. Ganoderic acid DM, the main component of Ganoderma lucidum, has been known for its medicinal effects such as anti-androgen and anti-proliferative activities. In this study, we investigated the inhibitory effects of ganoderic acid DM and its analog (methyl ganoderic acid DM and 7-oxo-methyl ganoderic acid Z) on osteoclastogenesis using RAW264 cell in vitro. Methyl ganoderic acid DM blocked osteoclastogenesis completely at 12.5 μM with low cytotoxicity less than 30%. On the other hands, ganoderic acid DM blocked osteoclastogenesis completely at the higher concentration of 50 μM, but 7-oxo-methyl ganoderic acid Z did not up to 100 μM. These results implicated the carbonyl group at C-3 is essentially for selective osteoclastogenesis inhibitory activity, and methyl esters at C-26 should play an important role in enhancing its osteoclastogenesis inhibitory activity

Keyword: Ganoderma lucidum, methyl ganoderic acid DM, osteoporosis, rheumatoid arthritis.


Article Information


Identifiers and Pagination:

Year: 2009
Volume: 2
First Page: 37
Last Page: 42
Publisher Id: TOBCJ-2-37
DOI: 10.2174/1874847300902010037

Article History:

Received Date: 10/7/2009
Revision Received Date: 30/7/2009
Acceptance Date: 2/8/2009
Electronic publication date: 26/11/2009
Collection year: 2009

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© Liu et al.; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka, 812-8581, Japan; Tel: +81-92-642-3002; Fax: +81-92-642-3002; E-mail: shimizu@agr.kyushu-u.ac.jp



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