The Open Bioactive Compounds Journal


ISSN: 1874-8473 ― Volume 8, 2020

Chemical Composition and Biological Activity of the Essential Oil and Solvent Extracts of Scaligeria Nodosa

Amir Reza Jassbi*, Mehdi Zare, Fatemeh Heidary Jamebozorgi
Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran



The essential oil and three solvent extracts of the aerial parts of Scaligeria nodosa (Boiss.) that were collected in Bamu Mountains (Iran), were screened for their antioxidant, antimicrobial properties and total phenolic contents for the first time.


The essential oil was extracted by hydrodistillation and analyzed by capillary gas chromatography-mass spectrometry (GC-MS) and GC flame ionization detector (GC-FID).


Forty five components were identified in the oil, among them, germacrene D (18.1±0.1%), bicyclogermacrene (1.4±0.0%), and spathunelnol (2.7±0.0%) were the major sesquiterpenoids, n-tetradecanol (4.9±0.0%) was the most abundant fatty alcohol and diisobuthyl phthalate (43.9±0.2%) was the most abundant constituent. The extracts of aerial parts of Sc. nodosa were prepared using different solvents; dichloromethane (DCM), methanol (MeOH) and MeOH: H2O (80:20). Antibacterial activity of the oil and each solvent extract was tested against three Gram-positive and three Gram-negative bacteria by nutrient broth micro dilution method. Among the tested microorganisms, Staphylococcus epidermidis (IC50 1.25-5mg/ml), Bacillus subtilis (IC50 1.25mg/ml) and Escherichia coli (IC50 1.25mg/ml) were the most susceptible to the applied oils and the extracts. The antioxidant potential and total phenol contents of the extracts were assessed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and Folin- Ciocalteu reagent, respectively. Methanol and 80% methanol extracts of the plant showed relatively weak DPPH radical scavenging activity and low amounts of total phenol contents.

Keywords: Scaligeria nodosa, Apiaceae, Essential oil, Antibacterial, Antioxidant, Gas chromatography.

Article Information

Identifiers and Pagination:

Year: 2017
Volume: 5
First Page: 16
Last Page: 22
Publisher Id: TOBCJ-5-16
DOI: 10.2174/1874847301005010016

Article History:

Received Date: 23/05/2017
Revision Received Date: 23/08/2017
Acceptance Date: 24/08/2017
Electronic publication date: 22/09/2017
Collection year: 2017

© 2017 Jassbi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at Medicinal and Natural Products Chemistry Research Center, Shahid Abaeiyan Ave., Zip: 71348-53734, Shiraz, Iran, Tel: +98-071-32303872, Fax: +98-071-32332225; E-mails:;

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Department of Pharmacy, World University of Bangladesh, Bangladesh

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