The Open Bioactive Compounds Journal




ISSN: 1874-8473 ― Volume 7, 2019
RESEARCH ARTICLE

Justification of Traditional Uses of Asparagus Racemosus (Shatavari) - A Miracle Herb



Samira Karim, Md. Shariful Islam, Zarin Tasnim, Farhina R. Laboni, Azima S. Julie, Zubair K. Labu*
Department of Pharmacy, World University of Bangladesh, 151/8 Green road, Dhaka 1205, Bangladesh

Abstract

Objective:

The ethanolic plant extracts of Asparagus racemosus and their partitionates were assessed for thrombolytic, membrane stabilizing, antimicrobial and antioxidant activity in vitro.

Methods:

The collected plant was dried and grinded. The coarse powder was shocked in 2000 mL of 90% methanol for several days then filtrated. At 40°C the volume of crude ethanolic extract (CEE) was reduced by a vacuum rotary evaporator followed by concentrated aqueous ethanol extractive was fractionated into petroleum ether (PSF), carbon tetrachloride (CTSF), chloroform soluble fraction (CSF) and aqueous (AQSF) soluble fractions.

Results:

In thrombolytic assay among all the extractives, carbon tetrachloride soluble fraction (CTSF) showed the highest clot lysis (41.48 ± 0.43%) activity as compared with standard streptokinase (65.16 ± 0.16%). With respect to the membrane stabilizing activity, chloroform soluble fraction (CSF) profoundly inhibited the lysis of erythrocytes (80.86 ± 0.36%) induced by osmosis, whereas reference standard acetyl salicylic acid (ASA) resulted in (88.99 ± 0.39%) inhibition of lysis. On the other hand, CTSF showed slightly higher level of protection against heat-induced hemolysis (85.68 ± 0.75%) as same as with ASA, (85.68 ± 0.75%)). In antimicrobial investigation, crude ethanol extract (CEE) and their partitioning fractions exhibited moderate inhibition of growth of some examined bacteria. The total phenolic content was found maximum (930.94 mg of GAE/gm) in CEE of A. racemosus. The antioxidant potentials in term of DPPH free radical scavenging assay showed EC50 values 2.62 μg/mL by aqueous soluble fraction (AQSF) in comparison to ascorbic acid 2.48 μg/mL as a reference standard.

Conclusions:

This study was conducted to validate the A. racemosus plant as thrombolytic, membrane stabilizing agent, antimicrobial and antioxidant.

Keywords: Asparagus racemosus, Thrombolytic, Membrane stabilizing, Antimicrobial, Antioxidant activity.


Article Information


Identifiers and Pagination:

Year: 2017
Volume: 5
First Page: 9
Last Page: 15
Publisher Id: TOBCJ-5-9
DOI: 10.2174/1874847301705010009

Article History:

Received Date: 22/05/2017
Revision Received Date: 22/07/2017
Acceptance Date: 25/08/2017
Electronic publication date: 22/09/2017
Collection year: 2017

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© 2017 Karim et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Department of Pharmacy, World University of Bangladesh, 151/8 Green road, Dhaka 1205, Bangladesh, Tel: 01558388956; E-mail: zubair.labu@yahoo.com



Endorsements



"It is an honor for us to publish our article in Open bioactive compound journal. The journal follows single blind peer review and plagiarism checking policy which is appreciable. I think soon your journal will attain high impact factor journals."


Zubair K. Labu
Department of Pharmacy, World University of Bangladesh, Bangladesh


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