The Open Bioactive Compounds Journal


ISSN: 1874-8473 ― Volume 8, 2020

Preparation, Characterization and Antimicrobial Activity of Schiff Base of (E) - N - (4-(Thiophen-2-ylmethyleneamino) Phenylsulfonyl) Acetamide Metal Complexes

Ahmad S. Abu-Khadra1, *, Ahmed S. Afify2, Amr Mohamed3, 4, Rabie S. Farag5, Hassan Y. Aboul-Enein6, *
1 Department of Basic Science, Faculty of Engineering Science, Sinai University, North Sinai, Egypt
2 Department of Applied Science and Technology, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129Torino, Italy
3 Department of Chemistry, Faculty of Science, Taibah University, 41411-Al-Madinah, Saudi Arabia
4 The Higher Institute of Optics Technology (HIOT), Heliopolis, 17361-Cairo, Egypt
5 Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt
6 Pharmaceutical and Medicinal Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Cairo12622, Egypt



Metal complexes of (E)-N-(4-(thiophen-2-ylmethyleneamino) phenylsulfonyl) acetamide (S.TH) Schiff bases derived from sulfacetamide (N-[4-(amino-phenyl) sulfonil] acetamide) and 2-thiophenecarboxaldehyde were synthesized and characterized.

Methods and Results:

The synthesized compositions have been characterized using different physico-chemical techniques. The investigation included elemental analysis, melting point measurements, proton NMR, UV spectroscopy, FT-IR, magnetic susceptibility, conductance measurements, mass spectral analysis, and inductively coupled plasma mass spectrometry (ICP-MS) for determining the concentrations of metal ions. The measured values for molar conductance indicated that the majority of the prepared complexes were nonelectrolytes. The biological activity of the prepared compositions has been investigated.


Spectroscopic studies suggested that most of the complexes were coordinated in a regular octahedral arrangement where S.TH ligand and the central metal atom were coordinated through two N amino azomethine groups (−HC=N−) and two sulfur atoms of S thiophene rings in 2L:1M molar ratio. Complexes have shown a promising activity upon screening for the antibacterial characteristics, and antifungal (Aspergillus fumigates and Candida albicans)

Keywords: Thiohene carboxaldehyde, Transition metal complexes, Sulfacetamide, inductively coupled plasma (ICP-MS), Thiophene rings, Anticonvulsant activity.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 6
First Page: 1
Last Page: 10
Publisher Id: TOBCJ-6-1
DOI: 10.2174/1874847301806010001

Article History:

Received Date: 07/12/2017
Revision Received Date: 27/01/2018
Acceptance Date: 29/01/2018
Electronic publication date: 21/02/2018
Collection year: 2018

© 2018 Abu-Khadra et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Pharmaceutical and Medicinal Chemistry Department, National Research Centre, Pharmaceutical and Drug Industries Research Division, Professor Hassan Y. Aboul-Enein, Cairo, Egypt; Tel:+201003678948; E-mails:,

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