The Open Bioactive Compounds Journal

ISSN: 1874-8473 ― Volume 8, 2020

Phytochemicals from Citrus Limon Juice as Potential Antibacterial Agents

Nitika Singh1, Jyotsna Jaiswal1, Priyanka Tiwari1, Bechan Sharma1, *
1 Department of Biochemistry, Faculty of Science, University of Allahabad, Allahabad-211002, India



Citrus limon (lemon) belongs to the Rutaceae family and has great therapeutic applications. The chemical ingredients of C. limon have been used in the formulation of several ethnic herbal medicines. The application of antibiotics has shown the development of drug resistance in antibacterial drugs. Due to the drug-resistant nature of microorganisms, there is an urgent need to develop a novel drug active against wildtype and MDR resistant strains of pathogens.


The present study is an endeavor to characterize the juice of C. limon towards its total antioxidants potential activity (FRAP), DPPH and antibacterial efficacy.

Methods and Materials:

The antimicrobial activity was evaluated using different bacterial species such as Salmonella typhi, Neisseria gonorrhoeae, Citrobacter species, Shigella flexneri and Staphylococcus epidermidis.


The results of the present study indicated the antibacterial potential of C. limon fruit juice. Among the tested bacterial species, Shigella flexneri displayed maximum inhibition followed by the other microbes such as Staphylococcus epidermidis, Citrobacter species and Salmonella typhi.


These findings may be utilized in the development of cost effective, safe and efficient novel drugs active against several pathogenic multi drug-resistant microorganisms.

Keywords: Antibacterial, Bacterial species, Citrus limon, Multi drugs resistance, Phytochemicals, Antimicrobial activity.

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 8
First Page: 1
Last Page: 6
Publisher Id: TOBCJ-8-1
DOI: 10.2174/1874847302008010001

Article History:

Received Date: 07/11/2019
Revision Received Date: 11/12/2019
Acceptance Date: 06/01/2020
Electronic publication date: 14/02/2020
Collection year: 2020

© 2020 Singh et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Biochemistry, Faculty of Science, University of Allahabad, Allahabad-211002, India;
Tel: +91-9415715639; E-mail:

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Department of Pharmacy, World University of Bangladesh, Bangladesh

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