The Open Biochemistry Journal

ISSN: 1874-091X ― Volume 14, 2020

Effects of Glucan and Vitamin D Supplementation on Obesity and Lipid Metabolism in Diabetic Retinopathy

Martina Závorková1, Vaclav Vetvicka2, *, Josef Richter3, Vlastimil Kral3, Ivana Liehnova1, Dobiasova L. Rajnohova3
1 Official Clinic of UJEP Masaryk Hospital, Regional Health, Usti and Labem, Czech Republic
2 University of Louisville, Department of Pathology, Louisville, KY, USA
3 Health Institute with headquarters in Usti and Labem, Usti and Labem, Czech Republic



Diabetes mellitus is a chronic disease manifested by an increase of blood glucose.


To evaluate the effects of glucan and vitamin D supplementation in patients with diabetic retinopathy.


We evaluated the effects of 3-month supplementation with glucan and vitamin D in 54 patients with diabetic retinopathy. We measured levels of vitamin D, cholesterol, HDL cholesterol, and triglycerides.


The supplementation strongly decreased the cholesterol levels and improved the levels of HDL cholesterol. In addition, vitamin D levels were strongly improved, but still not at optimal values.


From our data, we concluded that glucan and vitamin D supplementation strongly influence lipid metabolism and have positive effects on human health.

Keywords: Glucan, Vitamin D, Diabetes, Obesity, Diabetic retinopathy, Supplementation, Clinical trials.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 36
Last Page: 45
Publisher Id: TOBIOCJ-12-36
DOI: 10.2174/1874091X01812010036

Article History:

Received Date: 23/11/2017
Revision Received Date: 19/03/2018
Acceptance Date: 22/03/2018
Electronic publication date: 30/03/2018
Collection year: 2018

© 2018 Závorková et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pathology, University of Louisville, Vaclav Vetvicka, 511 S. Floyd, Louisville, KY 40202, USA; Tel: 5028521612; E-mail:

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