REVIEW ARTICLE
Vitamin D and Multiple Sclerosis: An Open-Ended Story
Concetta Scazzone1, *, Luisa Agnello1, *, Bruna Lo Sasso1, Anna Maria Ciaccio2, Rosaria V Giglio1, Giulia Bivona1, #, Marcello Ciaccio1, 3, #, *
Article Information
Identifiers and Pagination:
Year: 2019Volume: 13
First Page: 88
Last Page: 98
Publisher ID: TOBIOCJ-13-88
DOI: 10.2174/1874091X01913010088
Article History:
Received Date: 25/09/2019Revision Received Date: 09/12/2019
Acceptance Date: 13/12/2019
Electronic publication date: 31/12/2019
Collection year: 2019
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Multiple Sclerosis (MS) is a chronic inflammatory autoimmune disease of the Central Nervous System (CNS). Genetic, epigenetic and environmental factors interact together, contributing to the complex pathogenesis of the disease. In the last decades, the role of hypovitaminosis D on MS risk was hypothesised. Several factors drive the regulation of vitamin D status, including genetics. The current review summarises the literature evidence on the association between vitamin D and MS, with a focus on the genetic polymorphisms in vitamin D-related genes. The variants of the genes codifying Vitamin D Receptor (VDR), Vitamin D Binding Protein (VDBP) and CYP enzymes have been investigated, but the findings are controversial. Only a few studies have addressed the role of DHCR7 polymorphisms in MS risk.
