The Open Biochemistry Journal

ISSN: ― Volume ,

β-Glucan Improves Conditions of Chronic Fatigue in Mice by Stimulation of Immunity

Vaclav Vetvicka1, *, Jana Vetvickova1
1 Department of Pathology, University of Louisville, Louisville, KY, USA



Various natural molecules have been studied for the enhancement of physical endurance. Glucan has been found to improve various stress-related conditions and to improve fatigue and endurance.


In this study, we evaluation of glucan effects on some reactions involved in chronic fatigue has been focused.


Phagocytosis of neutrophils, the production of IL-2, IL-4, and IL-10 by spleen cells, and levels of antioxidant glutathione and oxidative stress marker superoxide dismutase in brain were measured. In addition, the effects of glucan on water immersion and on rotarod were also measured.


The glucan supplementation strongly improved the suppressed phagocytosis and changes in cytokine and levels of oxidative stress markers caused by fatigue. In addition, glucan supplementation also increased the motor functioning of tested animals.


Our data suggested that anti-fatigue properties of glucan are related to its well-established effects as stimulator of immune reactions.

Keywords: Glucan, Immunity, Fatigue, Cytokine, Immune reaction, Antioxidant glutathione.

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 14
First Page: 1
Last Page: 8
Publisher Id: TOBIOCJ-14-1
DOI: 10.2174/1874091X02014010001

Article History:

Received Date: 02/10/2019
Revision Received Date: 10/12/2019
Acceptance Date: 13/12/2019
Electronic publication date: 18/02/2020
Collection year: 2020

© 2019 Vetvicka and Vetvickova .

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pathology, University of Louisville, Louisville, KY 40202, USA; Tel: 5028521612; Fax: 502-852-1177 E-mail:

Track Your Manuscript:


"We have always had a fruitful cooperation and long-term experience of publishing with Bentham Open."

"A number of our original papers have appeared in its different journals, as the Bentham Open Publishers provides sufficient research in the field of science and technologies (belonging to the pharmaceutical, biotechnology, biomedical industries etc). The staff of the Bentham Open always treat our papers very seriously and gently during the rutile paper reviewing process, so far we always felt their kindness and highly cooperative support. Today, Bentham Open is providing a great support to science and research, giving opportunities of high standard publishing as well as promoting and enhancing selected papers around the world through communication and exchange of global scientific education."

Kholmirzo T. Kholmurodov
Leading Scientist
FLNP (Frank Laboratory of Neutron Physics) JINR (Joint Institute of Nuclear Research) Moscow region, Russia

Browse Contents

Webmaster Contact:
Copyright © 2021 Bentham Open