The Open Biochemistry Journal

ISSN: ― Volume ,

Nitric Oxide Balance in Health and Diseases: Implications for New Treatment Strategies

Musbau A. Akanji1, Anne A. Adeyanju2, Damilare Rotimi3, Oluyomi S. Adeyemi3, *
1 Department of Biochemistry, University of Ilorin, PMB 1515, Ilorin, Nigeria
2 Department of Biological Sciences, Kola Daisi University, Ibadan, PMB 84, Oyo State, Nigeria
3 Department of Biochemistry, Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran - 251101, Nigeria


Nitric Oxide (NO) is an essential signaling molecule with diverse physiological functions in humans. The steady-state concentration and site of production of nitric oxide determine its effects in biological systems. The human cells are exposed to both beneficial and harmful effects of NO. These dual effects of NO could depend on its local concentration in the cells. Additionally, the rate of synthesis, translocation, direct interaction with other molecules, and signals contribute to the biochemical and physiological effects of NO. In this review, the biochemical and physiological role of NO, particularly in health and disease as touching on cell signaling, oxidative stress, immunity, as well as cardiovascular protection amongst others, is focused on. Therefore, this review objectively discusses the dual functionality of NO in living cells.

Keywords: Nitric oxide, Cellular signaling, Oxidative stress, Vasoactive substances, Vasoconstriction, Vasodilation.

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 14
First Page: 25
Last Page: 32
Publisher Id: TOBIOCJ-14-25
DOI: 10.2174/1874091X02014010025

Article History:

Received Date: 24/2/2020
Revision Received Date: 10/5/2020
Acceptance Date: 11/5/2020
Electronic publication date: 31/07/2020
Collection year: 2020

© 2020 Akanji et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Biochemistry, The Medicinal Biochemistry, Nanomedicine & Toxicology Laboratory, Landmark University, PMB 1001, Omu-Aran - 251101, Nigeria; Tel: +234 7034 50 7902; E-mail:

Track Your Manuscript:


"We have always had a fruitful cooperation and long-term experience of publishing with Bentham Open."

"A number of our original papers have appeared in its different journals, as the Bentham Open Publishers provides sufficient research in the field of science and technologies (belonging to the pharmaceutical, biotechnology, biomedical industries etc). The staff of the Bentham Open always treat our papers very seriously and gently during the rutile paper reviewing process, so far we always felt their kindness and highly cooperative support. Today, Bentham Open is providing a great support to science and research, giving opportunities of high standard publishing as well as promoting and enhancing selected papers around the world through communication and exchange of global scientific education."

Kholmirzo T. Kholmurodov
Leading Scientist
FLNP (Frank Laboratory of Neutron Physics) JINR (Joint Institute of Nuclear Research) Moscow region, Russia

Browse Contents

Webmaster Contact:
Copyright © 2021 Bentham Open