The Teratogenic Mechanism of Echinochrome as a Hypoglycemic Agent on Wistar Rats
Ayman S. Mohamed1, *, Eman Y. Salah EL Din2, Neveen A. Farag2, Abdel Rahman A. Tawfik2
1 Department of Physiology Zoology, Faculty of Science, Cairo University, 12613, Giza, Egypt
2 Department Comparative Anatomy and Embryology Zoology, Faculty of Science, Cairo University, Giza, Egypt
Echinochrome (Ech) is the active ingredient in the Histochrome drug, which possesses strong antioxidant, hypolipidemic and hypoglycemic activity.
The present work aimed to characterize the malformations induced by moderate and high dose of Ech during pregnancy.
In this study, eighteen (18) female pregnant rats were assigned into 3 groups (6 rats/ group); control group, low dose Ech (0.1 mg/kg) and high dose Ech (1 mg/kg).
The high dose of Ech caused a significant decrease in the number of embryos, uteri weight, body weight gain, placenta weight, and embryo weight and length. Also, the high dose led to a significant increase in serum AST, ALT, ALP, urea and uric acid of mothers.
Our findings revealed the first teratogenic effects of high dose Ech. The teratogenic mechanism of Ech works through induction of the hypoglycemic condition in pregnant rats.
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