We quantified the main phospholipids of erythrocyte membranes and lipid profile from patients with coronary arterial disease (CAD). 202 patients between 22 and 86 years were classified in two groups: a group with CAD greater to or equal to 50% (CAD ≥ 50%) and a second group with CAD between zero and less than 50% (CAD<50%). Total phos-pholipids was,161.1 ± 12.0 nmol Ptotal/mg protein for patients with CAD and 137.7 ± 17.6 nmol Ptotal/mg protein for the patients with CAD < 50% (p=0.038). In the group of patients with CAD ≥ 50%, we found a linear correlation between sphingomyelin and total cholesterol (r = 0.69) and sphingomyelin and low-density lipoproteins cholesterol (LDL-c) (r = 0.74). This study found that sphingomyelin from membrane is directly related to plasma cholesterol and LDL in patients with CAD ≥ 50%.