The Open Clinical Biochemistry Journal

Formerly: The Open Clinical Chemistry Journal


ISSN: 2588-7785 ― Volume 9, 2019

The Effect of Lycopene Treatment on Oxidative DNA Damage of Experimental Diabetic Rats

F. Karahan1, S. Dede1, *, E. Ceylan2
1 Biochemistry Department, Veterinary Medicine School, Van Yuzuncu Yil University, Van, 65080, Turkey.
2 Internal Disease Department, Veterinary Medicine School, Ankara University, Ankara, Turkey



Lycopene is a carotenoid with anti-inflammatory and antioxidant properties. The aim of this study was to determine the effects of lycopene on oxidative DNA damage levels in experimental diabetic rats.

Subjects and Methods:

Four experimental groups, each consisting of 7 rats, were prepared as Controls, Diabetes (D), Lycopene-treated diabetes (DL) and Lycopene (L). STZ (45 mg/kg) was administered to the diabetic groups intraperitoneally in a single dose. Lycopene was administered to the L and DL groups (10 mg lycopene/kg/day). The test procedure continued for four weeks. To understand the occurrence of diabetic conditions, serum glucose and HbA1c% in the whole blood were determined. The 8-OHdG levels, a marker of oxidative DNA damage, were determined in the blood serum.


Blood glucose and HbA1c% were higher in the DL group than in the control group and L group (p <0.05) and lower in the D group (p <0.05). 8-OHdG levels were higher in D group than the other groups (p <0.05) while 8-OHdG levels in DL group were lower than D group (p <0.05) and approximated to the control group.


It can be suggested that lycopene may be described as a protective agent to prevent oxidative DNA damage originated from diabetes.

Keywords: Oxidative DNA damage, Diabetes, Lycopene, Rats, STZ, Mutagenesis.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 8
First Page: 1
Last Page: 6
Publisher Id: TOCCHEMJ-8-1
DOI: 10.2174/2588778501808010001

Article History:

Received Date: 13/2/2018
Revision Received Date: 8/3/2018
Acceptance Date: 31/3/2018
Electronic publication date: 30/04/2018
Collection year: 2018

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© 2018 Karahan et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Biochemistry Department, Van Yuzuncu Yil University, Veterinary Medicine School, Van, 65080, Turkey; Tel: +904322251027/1520; Fax: +904322251127; E-mail:


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