The Open Clinical Cancer Journal




(Discontinued)

ISSN: 1874-1894 ― Volume 5, 2011

Metabolic Profile of Breast Cancer in a Population of Women in Southern Spain



Juan-Bosco Lopez-Saez*, Jose Antonio Martinez-Rubio, Maria Montes Alvarez, Carmen Gonzalez Carrera, Margarita Dominguez Villar, Antonio Garcia de Lomas Mier, Charo Doménech , Avelino Senra-Varela
Departamento de Medicina, Facultad de Medicina, Universidad de Cádiz, Cádiz, Spain

Abstract

Background:

There are indications that mortality in breast cancer is related with dietary factors, but no study has been large enough to characterise reliably how, this risk is influenced. To establish a logistic regression equation that would predict breast cancer from factors in the endocrinological and metabolic profile, we studied endocrinological and metabolic risk factors that are modified by the diet, in a population of women with breast cancer in southern Spain.

Patients and Methods:

We carried out a simple a case-control study comparing 204 women with breast cancer (96 premenopausal and 108 postmenopausal women) and 250 healthy control subjects. The predictive variables were basal glycaemia, insulin, glycosylated haemoglobin (HbA1c), C-peptide, insulin-like growth factor-I (IGF-I), total cholesterol, triglycerides, high density lipoprotein-c (HDL-C), low density lipoprotein-c (LDL-C), selenium and Quetelet index (BMI).

Results:

The metabolic profile differed between pre- and postmenopausal patients, and metabolic alterations were greater in postmenopausal than in premenopausal women. The differences between healthy subjects and breast cancer patients were clearly significant.

Conclusions:

Our findings have several potential practical applications in the early detection of breast cancer, especially in premenopausal women; in primary prevention; and in the development of a mathematical model of breast carcinogenesis.

Keywords: Case-control study, breast cancer, carcinogenesis, metabolic profile.


Article Information


Identifiers and Pagination:

Year: 2008
Volume: 2
First Page: 1
Last Page: 6
Publisher Id: TOCCJ-2-1
DOI: 10.2174/1874189400802010001

Article History:

Electronic publication date: 18 /1/2008
Collection year: 2008

Bentham Science Publishers Ltd.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.


* Address correspondence to this author at the Departamento de Medicina, Universidad de Cádiz, c/. Dr. Marañón, nº 6, 11002-Cádiz, Spain; Tel: +34- 956-015324; Fax: +34-956-015280; E-mail: juanbosco.lopez@uca.es


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