Metabolic Profile of Breast Cancer in a Population of Women in Southern Spain
Juan-Bosco Lopez-Saez*, Jose Antonio Martinez-Rubio, Maria Montes Alvarez, Carmen Gonzalez Carrera, Margarita Dominguez Villar, Antonio Garcia de Lomas Mier, Charo Doménech , Avelino Senra-Varela
Departamento de Medicina, Facultad de Medicina, Universidad de Cádiz, Cádiz, Spain
There are indications that mortality in breast cancer is related with dietary factors, but no study
has been large enough to characterise reliably how, this risk is influenced. To establish a logistic regression equation that
would predict breast cancer from factors in the endocrinological and metabolic profile, we studied endocrinological and
metabolic risk factors that are modified by the diet, in a population of women with breast cancer in southern Spain.
Patients and Methods:
We carried out a simple a case-control study comparing 204 women with breast cancer (96
premenopausal and 108 postmenopausal women) and 250 healthy control subjects. The predictive variables were basal
glycaemia, insulin, glycosylated haemoglobin (HbA1c), C-peptide, insulin-like growth factor-I (IGF-I), total cholesterol,
triglycerides, high density lipoprotein-c (HDL-C), low density lipoprotein-c (LDL-C), selenium and Quetelet index
The metabolic profile differed between pre- and postmenopausal patients, and metabolic alterations were greater in postmenopausal than in premenopausal women. The differences between healthy subjects and breast cancer patients were clearly significant.
Our findings have several potential practical applications in the early detection of breast cancer, especially
in premenopausal women; in primary prevention; and in the development of a mathematical model of breast carcinogenesis.
Keywords: Case-control study, breast cancer, carcinogenesis, metabolic profile.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
* Address correspondence to this author at the Departamento de Medicina, Universidad de Cádiz, c/. Dr. Marañón, nº 6, 11002-Cádiz, Spain; Tel: +34-
956-015324; Fax: +34-956-015280; E-mail: firstname.lastname@example.org