Redox Status and Ascorbic Acid in Carcinoma of Head and Neck is Correlated to Clinical Response
Aashita Gupta1, Jitendra Verma2, M.L.B. Bhatt2 , M.K. Misra*, 1
1 Department of Biochemistry, University of Lucknow, Lucknow
2 Department of Radiotherapy, CSM Medical University, Lucknow
Abstract
Human cell normally functions in a reduced state and a disturbance in the redox system precedes many pathophysiological conditions, including cancer. Radiation therapy exerts its own cytotoxic actions via production of free radicals in the body, which in turn, trigger many signaling pathways leading to apoptotic death of malignant cells but a systemic oxidative stress may intensify the condition of the disease. Ascorbic acid and thiols are the main plasma antioxidants which help fight these free radicals, and may correlate to the clinical response in head and neck cancer patients. The results of the present study indicate that thiols do not correlate but ascorbic acid correlates well to the clinical response.
Keywords: Redox system, ascorbic acid, head and neck cancer, radiation therapy.
Article Information
Article History:
Received Date: 29/8/2009
Revision Received Date: 31/3/2010
Acceptance Date: 31/3/2010
Electronic publication date: 13/5/2010
Collection year: 2010
© Gupta etal.; Licensee Bentham Open.
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (
http: //creativecommons.org/licenses/by-nc/3.0/ which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
* Address correspondence to this author at the Department of Biochemistry, University of Lucknow, Lucknow-226007, India; Tel: +91-0522-2441064
E-mail: profmkmisra@sify.com
Open Peer Review Details |
Manuscript submitted on 29-8-2009 |
Original Manuscript |
Redox Status and Ascorbic Acid in Carcinoma of Head and Neck is Correlated to Clinical Response |