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Dissections of the cervical arteries are among the most frequent causes of juvenile strokes. The etiology and
pathogenesis of spontaneous dissections remain elusive. Best treatment remains to be defined. Here, we analyzed 71
consecutive patients from the Department of Neurology, University Hospital of Jena. We asked if immediate
anticoagulation or alternative treatment with ASA would affect outcome. Patients treated initially with i.v. ASA tended to
have a better outcome than patients who were anticoagulated (r=0.3; p<0.05). In heparin treated patients, an initial i.v.
bolus shortened the interval before the target PTT was reached by 1.3 days (p<0.05), yet did not affect neurological
outcome. Low NIHSS (National Institute of Health Stroke Scale) (r=-0.71; p<0.01) and high Barthel scores (r=0,77;
p<0.01) at presentation predicted a good outcome. In 14 of 52 patients, low TSH (thyroid- stimulating hormone) indicated
hyperthyreosis, while no patient was hypothyreotic. In 33 of 64 patients CRP (C-reactive protein) was elevated. These
findings merit validation in larger trials.