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The purpose of this study was to determine if any relationship exists between Estrogen Receptor (ER),
Progesterone Receptor (PR), Her2/neu, P53, and clinicopathological factors in female breast ductal carcinoma.
One hundred and thirty seven (IDC=124, NIDC=13) ductal carcinomas were clinicopathologically and immunohistochemically
analyzed and compared with 20 control cases of benign breast lesions in which assessment of Her-
2/neu, ER, PR, and P53 has been performed, prospectively. Chi-square analysis was then used to correlate the above observations.
The overall immunoexpression of ER, PR, Her2/neu and P53 were 43.8%, 27%, 30.6% and 48.9%,
respectively, of the 137 ductal carcinomas. A significant Positive association between ER or PR expression with lymph
node involvement was found ( p= 0.004, p= 0.022 respectively), while p53 was found to be negatively associated with
lymph nodes involvement (p= 0.03, 0.02, respectively). P53 also associated negatively to lymph node status (P=0.03) and
positively with borderline tumor grade (p= 0.03).
There are high rates of positive expression of ER, PR,
Her2/neu and P53 among Yamani women with breast ductal carcinoma.