Alternative splicing of mRNA precursors allows the synthesis of multiple mRNAs from a single primary
transcript, thus contributing to proteomic diversity in higher eukaryotes. Multiple studies demonstrate that alternative
splicing patterns are altered during cancer progression. Several different mechanisms can contribute to changes in the
regulation of alternative splicing. This report will provide an overview of how splicing microarrays and large-scale
sequencing are being used to identify splicing changes in breast and prostate cancer. Global analyses of splice variants
have identified cancer-specific splice variant patterns that have potential use as biomarkers and potentially have
prognostic value as well as may represent novel therapeutic targets. A description of specific splice variants with
differential expression in these cancers and their possible functions will be presented.