The Open Cardiovascular Medicine Journal

ISSN: 1874-1924 ― Volume 13, 2019

Hypoxic Pulmonary Vasoconstriction in Humans: Tale or Myth

A. Hussain1, *, M.S. Suleiman2, S.J. George2, M. Loubani1, A. Morice3
1 Department of Cardiothoracic Surgery, Castle Hill Hospital, Castle Road, Cottingham, HU16 5JQ, UK
2 School of Clinical Sciences, Bristol Royal Infirmary, Marlborough Street, Bristol, BS2 8HW, UK
3 Department of Respiratory Medicine, Castle Hill Hospital, Castle Road, Cottingham, HU16 5JQ, UK


Hypoxic Pulmonary vasoconstriction (HPV) describes the physiological adaptive process of lungs to preserves systemic oxygenation. It has clinical implications in the development of pulmonary hypertension which impacts on outcomes of patients undergoing cardiothoracic surgery. This review examines both acute and chronic hypoxic vasoconstriction focusing on the distinct clinical implications and highlights the role of calcium and mitochondria in acute versus the role of reactive oxygen species and Rho GTPases in chronic HPV. Furthermore it identifies gaps of knowledge and need for further research in humans to clearly define this phenomenon and the underlying mechanism.

Keywords: Hypoxic Pulmonary Vasoconstriction, Human, Acute hypoxia, Chronic hypoxia, Pulmonary hypertension.

Article Information

Identifiers and Pagination:

Year: 2017
Volume: 11
First Page: 1
Last Page: 13
Publisher Id: TOCMJ-11-1
DOI: 10.2174/1874192401711010001

Article History:

Received Date: 13/10/2016
Revision Received Date: 02/12/2016
Acceptance Date: 09/12/2016
Electronic publication date: 24/01/2017
Collection year: 2017

Article Metrics:

CrossRef Citations:

Total Statistics:

Full-Text HTML Views: 4270
Abstract HTML Views: 847
PDF Downloads: 502
ePub Downloads: 356
Total Views/Downloads: 5975

Unique Statistics:

Full-Text HTML Views: 783
Abstract HTML Views: 391
PDF Downloads: 260
ePub Downloads: 157
Total Views/Downloads: 1591
Geographical View

© Hussain et al.; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (, which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the Department of Cardiothoracic Surgery, Castle Hill Hospital, Castle Road, Cottingham, HU16 5JQ, UK; Tel: 0044-774-8019242; E-mail:


"I am very satisfied by all the services, friendly communication and the attention that was given to my manuscript. My sincere gratitude tou you and the entire team of Bentham Open"

Aristofanis Gikas
Health Centre of Kalivia, K
alivia, Attiki,

Browse Contents


Webmaster Contact:
Copyright © 2019 Bentham Open