Low HDL Cholesterol, Smoking and IL-13 R130Q Polymorphism are Associated with Myocardial Infarction in Greek Cypriot Males. A Pilot Study

Xenophontos, Stavroulla; Hadjivassiliou, Marilena; Karagrigoriou, Alexandros; Demetriou, Nafsika; Miltiadous, George; Marcou, Ioannis; Elisaf, Moses; Mikhailidis, Dimitri P; Cariolou, Marios A

Low HDL Cholesterol, Smoking and IL-13 R130Q Polymorphism are Associated with Myocardial Infarction in Greek Cypriot Males. A Pilot Study

Stavroulla Xenophontos¹, Marilena Hadjivassiliou¹, Alexandros Karagrigoriou², Nafsika Demetriou¹, George Miltiadous³, Ioannis Marcou⁴, Moses Elisaf³, Dimitri P Mikhailidis⁵, Marios A Cariolou^{*, 1}

¹ Department of Cardiovascular Genetics & The Laboratory of Forensic Genetics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus

² Mathematics and Statistics Department, University of Cyprus, Nicosia, Cyprus

³ Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece

⁴ Department of Internal Medicine, Nicosia General Hospital, Nicosia, Cyprus

⁵ Department of Clinical Biochemistry, Royal Free Hospital Campus, University College London, Pond Street, London, NW3 2 QG, UK

Article Information

Identifiers and Pagination:

Year: 2008
Volume: 2
First Page: 52
Last Page: 59
Publisher ID: TOCMJ-2-52
DOI: 10.2174/1874192400802010052

Article History:

Received Date: 24/6/2008
Revision Received Date: 2/7/2008
Acceptance Date: 4/7/2008
Electronic publication date: 22/7/2008
Collection year: 2008

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© Xenophontos et al.; Licensee Bentham Open

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

^* Address correspondence to this author at the Department of Cardiovascular Genetics & The Laboratory of Forensic Genetics, The Cyprus Institute of Neurology and Genetics, 6 Airport Avenue, 1683 Nicosia, Cyprus; Tel: 0035722392651; Fax: 0035722392638; E-mail: cariolou@cing.ac.cy

This study was carried out in Greek Cypriot males to identify risk factors that predispose to myocardial infarction (MI). Genetic and lipid risk factors were investigated for the first time in a Greek Cypriot male case-control study.Contrary to other studies, mean low density lipoprotein cholesterol did not differ between cases and controls. High density lipoprotein cholesterol on the other hand, although within normal range in cases and controls, was significantly higher in the control population. In agreement with many other studies, smoking was significantly more prevalent in cases compared with controls. In pooled cases and controls, smokers had a significantly lower HDL-C level compared with non-smokers. The frequency of the IL-13 R130Q homozygotes for the mutation (QQ), as well as the mutant allele were significantly higher in cases compared with controls. The IL-13 R130Q variant, or another locus, linked to it, may increase the risk of MI.

Key Words: Smoking, myocardial infarction, cholesterol, Cyprus .

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RESEARCH ARTICLE

Low HDL Cholesterol, Smoking and IL-13 R130Q Polymorphism are Associated with Myocardial Infarction in Greek Cypriot Males. A Pilot Study

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Abstract

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