High Sensitivity C - Reactive Protein is Associated with Diastolic Dysfunction in Young African Americans without Clinically Evident Cardiac Disease
Venkataraman Rajaram1, Arthur T Evans2, Gloria C Caldito3, Russell F Kelly4, Leon Fogelfeld5, Henry R Black6, Rami Doukky7, *
1 Section of Cardiology, Temple University Health Sciences Center, Philadelphia, PA, USA
2 Department of Medicine, John H Stroger, Jr. Hospital of Cook County, Chicago, IL, USA
3 Department of Biometry, Louisiana State University Health Sciences Center, Shreveport, LA, USA
4 Division of Cardiology, John H Stroger, Jr. Hospital of Cook County, Chicago, IL, USA
5 Division of Endocrinology, John H Stroger, Jr. Hospital of Cook County, Chicago, IL, USA
6 Center for the Prevention of Cardiovascular Disease, New York University, New York, NY, USA
7 Section of Cardiology, Rush University Medical Center and John H Stroger, Jr. Hospital of Cook County, Chicago, IL, USA
Diastolic dysfunction (DD) is associated with myocardial fibrosis mediated by inflammation. Higher levels of inflammation found in African Americans (AAs) may predict DD among asymptomatic individuals. We tested the hypothesis that high sensitivity C-reactive protein (hs-CRP), a biomarker of inflammation, is associated with DD in asymptomatic AAs.
We prospectively recruited 107 asymptomatic AAs without any history of cardiac, renal or inflammatory diseases or alcoholism. We measured hs-CRP and B-type Natriuretic peptide (BNP) levels and estimated left ventricular end diastolic pressure (LVEDP), mass and systolic function with echocardiography. Multivariate logistic regression analysis was used to define whether hs-CRP is an independent predictor of LVEDP.
Among 107 subjects: the mean age was 48±10 yrs, 58 (54%) were men, 59 (55%) had diabetes (DM), 48 (45%) had hypertension (HTN), the mean BMI was 30.5±4.8 and the mean ejection fraction was 63.1±5.8%. DD was present in 56(52%) subjects, 38 (36%) of whom also had a high LVEDP. On multivariate analysis, hs-CRP was independently associated with DD [odds ratio 3.36 (95% CI= 1.07 - 10.5, p = 0.04]. There was a 61% and 133% increase in the prevalence of any DD and DD with high LVEDP, respectively, between the lowest and the highest hs-CRP quartiles.
Diastolic dysfunction is prevalent among asymptomatic African Americans and it is independently associated with elevated level of hs-CRP, an inflammation marker.
Keywords: Diastolic dysfunction, Inflammation, High sensitivity C-reactive protein, Biomarkers..
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* Address correspondence to this author at the Rush University Medical Center, Section of Cardiology, Jelke # 1015d Chicago, IL 60612, USA; Tel: 312-563-2534; Fax: 312-942-6334; E-mail: email@example.com