The Open Cardiovascular Medicine Journal


ISSN: 1874-1924 ― Volume 10, 2016

HIV and HAART-Associated Dyslipidemia



Eoin R Feeney1, *, Patrick W.G Mallon 1, 2
1 HIV Molecular Research Group, School of Medicine and Medical Science, University College Dublin, Dublin, Ireland
2 Department of Infectious Diseases, Mater Misericordiae University Hospital, Dublin, Ireland

Abstract

Effective highly active antiretroviral therapy (HAART) for human immunodeficiency virus-1 (HIV) infection has led to marked improvement in life-expectancy for those infected with HIV. Despite reductions in the incidence of AIDS with effective treatment, patients continue to experience considerable morbidity and mortality from non-AIDS illness such as premature cardiovascular disease, liver failure and renal failure. These morbidities, particularly premature cardiovascular disease, are thought to be related to a combination of the effects of an ageing HIV-infected population coupled with long-term effects of HIV infection and antiretroviral therapy (ART). One of the principle drivers behind the well documented increase in the risk of cardiovascular disease in HIV-infected patients is dyslipidemia.

This review will focus on the clinical presentation of HIV and ART-associated dyslipidemia, what is known of its patho-physiology, including associations with use of specific antiretroviral medications, and suggest screening and management strategies.

Keywords: HIV, HAART, dyslipidemia, cholesterol, triglycerides, lipids..


Article Information


Identifiers and Pagination:

Year: 2011
Volume: 5
First Page: 49
Last Page: 63
Publisher Id: TOCMJ-5-49
DOI: 10.2174/1874192401105010049

Article History:

Received Date: 15/12/2010
Revision Received Date: 01/01/2011
Acceptance Date: 06/01/2011
Electronic publication date: 24/02/2011
Collection year: 2011

© Feeney and Mallon; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the School of Medicine and Medical Science, University College Dublin, Dublin 2, Ireland; Tel: +353 1 7166518; Fax: +353 1 7166335; E-mail: eoin.feeney@ucd.ie


Endorsements



"I am very satisfied by all the services, friendly communication and the attention that was given to my manuscript. My sincere gratitude tou you and the entire team of Bentham Open"


Aristofanis Gikas
Health Centre of Kalivia, K
alivia, Attiki,
Greece


SCImago Journal Ranking

SCImago Journal & Country Rank

Browse Contents


Webmaster Contact: urooj@benthamopen.com
Copyright © 2016 Bentham Open