The aim of this study was to assess whether preoperative and postoperative brain natriuretic peptide
(BNP) levels could be used as predictors of postoperative complications and outcome in patients with coronary artery disease
and ischemic heart failure undergoing on-pump or off-pump coronary artery bypass grafting surgery (CABG).
Methods and Results:
Fifty-eight patients (56 males and two females) with a median age of 65.3±9.9 years were included
in the study. Thirty-eight patients (65.5%) underwent on-pump CABG, and 20 patients (34.5%) underwent off-pump
CABG. BNP levels were determined within 24 hours before CABG and serially at 6 hours, 24 hours, 3, 7 and 30 days after
CABG. Creatine phosphokinase myocardial band (CK-MB) levels were measured 1, 3, and 7 days after CABG. BNP
and CK-MB levels did not differ significantly between the two groups at any time point. Preoperative BNP levels independently
predicted the occurrence of cardiogenic shock and more importantly, short-term mortality. Neither preoperative
left ventricular ejection fraction nor postoperative BNP or CK-MB levels at any time point showed any significant independent
prognostic value for any postoperative complication. Conclusion: Our results suggest that it may be prudent to
more closely monitor patients with higher preoperative BNP levels for possible postoperative complications.