The Open Dentistry Journal




ISSN: 1874-2106 ― Volume 13, 2019
CASE REPORT

Surgical Management of Granular Cell Tumor of the Orbit: Case Report and Literature Review



Jahan Abtahi*, Iman Malakuti, Aida Ajan
Department of Oral and Maxillofacial Surgery, Linköping University Hospital, SE-581 85 Linköping, Sweden

Abstract

Introduction:

Granular Cell Tumors (GCTs) of the orbit are rare-entity soft-tissue tumors, and few reports have been published in the literature. The treatment of the choice is total excision. Early diagnosis prior to surgery is valuable for the distinction of malignant from benign tumor.

Case presentation:

We report a case of a 55-year-old woman with a solitary slow-growing mass in the right orbit with the involvement of the rectus inferior muscle, and present a review of the recent literature. The lesion had a diameter of 1 cm and was noticed 2 years before the examination. Excisional biopsy confirmed the diagnosis of GCT. The tumor was resected through a retroseptal transconjunctival approach. The final histological examination revealed findings characteristic of GCT, including positive reaction for protein S-100, SOX10, and calcitonin and negative reaction for desmin, myogenin, Smooth Muscle Antigen (SMA), Melan-A, and HMB-45. There were no signs of malignancy in this sample. Disturbance of motility was not noted by the patient after surgery.

Conclusion:

GCT should be included in the differential diagnosis of intraorbital lesions, particularly those that involve the orbit muscles. A biopsy is recommended before surgical resection, to exclude malignancy and prevent radical resection.

Keywords: Granular cell tumor, Orbit, Protein S-100, Inferior rectus muscle, Magnetic resonance imaging, Biopsy.


Article Information


Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 33
Last Page: 40
Publisher Id: TODENTJ-13-33
DOI: 10.2174/1874210601913010033

Article History:

Received Date: 7/12/2018
Revision Received Date: 14/12/2018
Acceptance Date: 27/12/2018
Electronic publication date: 31/1/2019
Collection year: 2019

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© 2019 Abtahi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Department of Oral and Maxillofacial Surgery, Linköping University Hospital, SE-581 85 Linköping, Sweden; Tel: +46 101038551; Fax: +46 101038565; E-mail: Jahan.abtahi@regionostergotland.se


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