The Open Drug Safety Journal


ISSN: 1876-8180 ― Volume 4, 2013

Birth Outcomes of Pre-Eclamptic Pregnant Women With Vitamin E Supplementation – A Population-Based Study

Liza Bártfai1, Andrew E Czeizel*, 2, Ferenc Bánhidy3
1 Department of Pulmonology, Elisabeth Teaching Hospital, Sopron, Hungary;
2 Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary;
3 Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary


Objectives. To study the efficacy of vitamin E supplementation for the reduction of preterm birth/low birthweight newborns in pre-eclamptic pregnant women. Design. Comparison of the rate of preterm birth and low birthweight in pre-eclamptic pregnant women with or without vitamin E treatment. Setting. Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996. Population. Newborn infants in Hungarian population. Methods. Medically recorded pre-eclampsia and birth outcomes of pregnant women were evaluated. Main outcome measures. Preterm birth, low birthweight. Results. There was no lower incidence of pre-eclampsia after vitamin E treatment. Pregnant women with pre-eclampsia and without vitamin E treatment had a higher rate of preterm births (10.4% vs. 9.3%) and low birthweight newborns (7.8% vs. 5.6%) than the reference sample of 34,928 pregnant women without pre-eclampsia and without vitamin E treatment. The newborns of 936 pregnant women with pre-eclampsia and without vitamin E treatment had higher rate of preterm birth (10.4% vs. 8.6%; OR with 95% CI: 0.8, 0.7-0.9) than 81 pregnant women with pre-eclampsia but with vitamin E treatment. However, the rate of low birthweight newborns was somewhat but not significantly higher (8.6% vs. 7.8%; OR with 95 CI: 1.1, 0.8-1.4) in pregnant women with pre-eclampsia and with vitamin E treatment. There was very high rate of threatened abortion (45.7% vs. 15.3%) and threatened preterm delivery (27.2% vs. 13.5%) in 81 pre-eclamptic pregnant women with vitamin E treatment compared to the reference group. Conclusions. Vitamin E treatment reduced the rate of preterm birth in pregnant women with pre-eclampsia but not the rate of low birthweight newborns.

Keywords: Pre-eclampsia, vitamin E, preterm birth, low birthweight.

Article Information

Identifiers and Pagination:

Year: 2011
Volume: 2
First Page: 54
Last Page: 60
Publisher Id: TODSJ-2-54
DOI: 10.2174/1876818001102010054

Article History:

Received Date: 16/4/2011
Revision Received Date: 03/6/2011
Acceptance Date: 27/7/2011
Electronic publication date: 5/10/2011
Collection year: 2011

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© Bártfai et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Budapest, 1026. Törökvész lejtő 32, Hungary; Tel: 36-1-3944-712; Fax: 36-1-3944-712; E-mail:


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