The Open Drug Safety Journal




(Discontinued)

ISSN: 1876-8180 ― Volume 4, 2013

Birth Outcomes of Pre-Eclamptic Pregnant Women With Vitamin E Supplementation – A Population-Based Study



Liza Bártfai1, Andrew E Czeizel*, 2, Ferenc Bánhidy3
1 Department of Pulmonology, Elisabeth Teaching Hospital, Sopron, Hungary;
2 Foundation for the Community Control of Hereditary Diseases, Budapest, Hungary;
3 Second Department of Obstetrics and Gynecology, Semmelweis University, School of Medicine, Budapest, Hungary

Abstract

Objectives. To study the efficacy of vitamin E supplementation for the reduction of preterm birth/low birthweight newborns in pre-eclamptic pregnant women. Design. Comparison of the rate of preterm birth and low birthweight in pre-eclamptic pregnant women with or without vitamin E treatment. Setting. Hungarian Case-Control Surveillance System of Congenital Abnormalities, 1980-1996. Population. Newborn infants in Hungarian population. Methods. Medically recorded pre-eclampsia and birth outcomes of pregnant women were evaluated. Main outcome measures. Preterm birth, low birthweight. Results. There was no lower incidence of pre-eclampsia after vitamin E treatment. Pregnant women with pre-eclampsia and without vitamin E treatment had a higher rate of preterm births (10.4% vs. 9.3%) and low birthweight newborns (7.8% vs. 5.6%) than the reference sample of 34,928 pregnant women without pre-eclampsia and without vitamin E treatment. The newborns of 936 pregnant women with pre-eclampsia and without vitamin E treatment had higher rate of preterm birth (10.4% vs. 8.6%; OR with 95% CI: 0.8, 0.7-0.9) than 81 pregnant women with pre-eclampsia but with vitamin E treatment. However, the rate of low birthweight newborns was somewhat but not significantly higher (8.6% vs. 7.8%; OR with 95 CI: 1.1, 0.8-1.4) in pregnant women with pre-eclampsia and with vitamin E treatment. There was very high rate of threatened abortion (45.7% vs. 15.3%) and threatened preterm delivery (27.2% vs. 13.5%) in 81 pre-eclamptic pregnant women with vitamin E treatment compared to the reference group. Conclusions. Vitamin E treatment reduced the rate of preterm birth in pregnant women with pre-eclampsia but not the rate of low birthweight newborns.

Keywords: Pre-eclampsia, vitamin E, preterm birth, low birthweight.


Article Information


Identifiers and Pagination:

Year: 2011
Volume: 2
First Page: 54
Last Page: 60
Publisher Id: TODSJ-2-54
DOI: 10.2174/1876818001102010054

Article History:

Received Date: 16/4/2011
Revision Received Date: 03/6/2011
Acceptance Date: 27/7/2011
Electronic publication date: 5/10/2011
Collection year: 2011

© Bártfai et al.; Licensee Bentham Open.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.


* Address correspondence to this author at the Budapest, 1026. Törökvész lejtő 32, Hungary; Tel: 36-1-3944-712; Fax: 36-1-3944-712; E-mail: czeizel@interware.hu


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