As a realization of the energy cascade utilization, the regional energy system has the significant potential of energy saving. As a kind of renewable energy, river water source heat pump also can greatly reduce the energy consumption of refrigeration and heating system. Combining the regional energy and water source heat pump technology, to achieve cooling, heating and power supply for a plurality of block building is of great significance to reduce building energy consumption. This paper introduces a practical engineering case which combines the regional energy system of complex river water source heat pump, which provides a detailed analysis of the hydrology and water quality conditions of the river water source heat pump applications, and discusses the design methods of water intake and drainage system. The results show that the average temperature of cold season is about 23.5 °C, the heating season is about 13.2 °C; the abundant regional water flow can meet the water requirement of water source heat pump unit; the sediment concentration index cannot meet the requirement of river water source heat pump if the water enters the unit directly; the river water chemistry indicators (pH, Cl-, SO42-, total hardness, total iron) can meet the requirement of river water source heat pump, and it is not required to take special measures to solve the problem. However, the problem of sediment concentration of water must be solved.
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