Background: Asymmetric dimethylarginine (ADMA) has in some, but not all studies been associated with
insulin resistance (IR). We wanted to challenge the hypothesis that plasma ADMA levels are associated with IR in an
intervention study using an insulin sensitizing drug. Another aim of the study was to study daytime ADMA variation and
if food intake influence ADMA concentration.
Methods: Nine patients with diet treated type 2 diabetes were investigated with daytime profiles of ADMA (8 am-5 pm)
before and during treatment with rosiglitazone for 8 weeks. A control group matched for age and sex underwent a similar
investigation at baseline.
Results: After treatment with rosiglitazone, ADMA (0.63- 0.64 μmmol/L; p=0.26) and homocysteine (10.3 -10.6 μmol/L;
p=0.61) concentrations did not change. Postprandial (10 am – 5 pm) ADMA concentrations were 10% higher than fasting
morning levels (p=0.006) and this difference was similar for controls and diabetes patients both pre and post treatment
Conclusions: Treatment with rosiglitazone aiming to improve insulin sensitivity did not affect ADMA concentration in
type 2 diabetes patients.
The ADMA daytime variation and the relation to food intake appear to be a novel finding and should be considered in