SIRS/sepsis accounts for vast majority of deaths in ICU a medical ward department. More than
650,000 cases of sepsis are diagnosed in the United States annually, with 30-50% mortality and individually cost more
than 22,000 dollars.
Biomarkers could be useful tools for early risk stratification in these patients. Angiopioietin-2 (Ang-2) is a proinflammatory
mediator of endothelial injury, which has received considerable attention over the past decade but little is known
about its correlation with organ failure and mortality in SIRS/sepsis admitted to a medical ward.
Ang-2 plasma levels, Charlson index, SOFA and routine laboratory test were carried out in 80 SIRS patients
admitted to medical ward within 4 hours from diagnosis.
Survival and organ dysfunction in the following week were recorded.
Investigators were blinded from Ang-2 results.
Ang-2 plasma levels were higher in patients suffering from renal, pulmonary and hemostatic dysfunction (16, 6,
4% respectively) and patients who died within 1 week (11%). Ang-2 plasma levels higher than 15 μ/mL account for 13
fold increased risk of death with 94% negative predictive value.
Ang-2 plasma level at admission is predictive of early mortality and kidney, lung and hemostasis dysfunction
in SIRS/sepsis patients newly admitted in a medical ward.