The Open Hepatology Journal


ISSN: 1876-5173 ― Volume 3, 2011

Association of Tumor Necrosis Factor α and Manganese Superoxide Dismutase Polymorphisms in Patients with Non-Alcoholic Steatohepatitis from Northeast Mexico

The Open Hepatology Journal, 2011, 3: 1-6

Karina Trujillo-Murillo, Francisco J. Bosques-Padilla, Irma Calderón-Lozano, Sirelda Navar-Vizcarra, Elvira Garza-González, Alberto Niderhauser-García, Juan P. Flores-Gutiérrez, Pablo Zorrilla-Blanco, Ricardo Salinas-Garza, Ana M. Rivas-Estilla, Herminia G. Martínez-Rodríguez

Department of Biochemistry and Molecular Medicine, School of Medicine, Autonomous University of Nuevo Leon, Monterrey, NL, Mexico.

Electronic publication date 22/2/2011
[DOI: 10.2174/1876517301103010001]


Background and Aims:

Environmental and genetic factors play a role in the pathogenesis and natural history of non-alcoholic steatohepatitis (NASH). The aim of this study was to determine if the G-238A (allele TNFA) and G-308A (allele TNF2) tumor necrosis factor-alpha (TNF-α) and Ala9Val manganese superoxide dismutase (MnSOD) polymorphisms were associated with NASH in a case-control study of subjects from Northeast Mexico.


We analyzed DNA samples from 68 patients with NASH (50 women and 18 men; mean age ± SD, 33.9 ± 10.8 years; BMI 43.9 ± 7.2 kg/m2) and 100 healthy subjects (44 women and 56 men; mean age ± SD, 27.8 ± 10.8 years; BMI 23 ± 1.6 kg/m2). The diagnosis was based on liver biopsy reviewed by two pathologists blinded to clinical data. The polymorphisms were evaluated using the polymerase chain reaction-restriction fragment length polymorphism method.


The frequency of G-238A TNF-α and Ala9Val MnSOD polymorphisms in NASH patients was significantly higher in comparison with control subjects (OR = 3.06, 95% CI 1.29-7.33, p = 0.0047 and OR = 6.28, 95% CI 2.95-13.55, p = 0.001, respectively). In contrast, the G-308A TNF-α polymorphism did not show a statistical difference between either group (OR = 1.04, 95% CI 0.45-2.38, p = NS). Analyzed populations were in Hardy-Weinberg equilibrium.


Our results suggest that G-238A TNF-α and Ala9Val MnSOD polymorphisms, which are molecules involved in inflammation and cellular oxidative stress, could be associated with NASH. These data may contribute to understanding the genetic susceptibility to NASH.

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