The Open Hypertension Journal


ISSN: 1876-5262 ― Volume 12, 2020

Nocturnal Blood Pressure Decrease in Hypertensive Patients and Normotensives- Association with Obstructive Sleep Apnoea and Renal Function

Bodil G. Hornstrup1, 2, *, Jeppe B. Rosenbaek2, Nikolai Hoffmann-Petersen2, Pia H. Gjoerup2, Jost Wessels2, Thomas G. Lauridsen1, 2, Erling B. Pedersen1, Jesper N. Bech1, 2
1 University Clinic of Nephrology and Hypertension, Holstebro Hospital, Aarhus University, Holstebro, Denmark
2 Department of Medicine, Holstebro Hospital, Holstebro, Denmark



Blunted nocturnal Blood Pressure (BP) decrease is seen in patients with hypertension and obstructive sleep apnoea (OSA). The influence of OSA and renal function on nocturnal BP decrease is not fully clarified.


In this case control study of hypertensive patients and healthy controls, we aimed to analyse the relationship between nocturnal BP decrease on one hand and presence of OSA, renal function, plasma levels of syndecan and vasoactive hormones, and urinary sodium excretion on the other.


In 75 hypertensive patients and 56 controls, we performed brachial and central 24h ambulatory BP measurement and cardio respiratory monitoring. We measured syndecan, renin, angiotensinII, aldosterone, vasopressin, and brain natriuretic peptide in plasma and 24h urinary excretion of sodium, aquaporin2, and a component of the epithelial sodium channel (u-ENaCγ).


Nocturnal BP decrease was lower in patients than controls, brachial (13% versus 17%, p=0.001) and central (8% versus 10%, p=0.019). Moderate-to-severe OSA was present in 13% of patients, 2% of controls (p<0.005). Neither brachial nor central nocturnal BP decrease was associated with OSA, renal function, plasma levels of vasoactive hormones, syndecan-1, or urinary sodium excretion. P-syndecan and u-ENaCɣ were higher in patients than controls.


Both brachial and central nocturnal BP decrease was lower in patients than in controls. Neither brachial nor central nocturnal BP decrease was associated with the presence of OSA, renal function, or plasma levels of vasoactive hormones. Increased syndecan in plasma in hypertensive patients suggested damage to the endothelial glycocalyx.

Keywords: Nocturnal blood pressure decrease, Hypertension, Obstructive sleep apnoea, Renal function, Central blood pressure, Syndecan.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 10
First Page: 28
Last Page: 40
Publisher Id: TOHYPERJ-10-28
DOI: 10.2174/1876526201810010028

Article History:

Received Date: 19/4/2018
Revision Received Date: 26/7/2018
Acceptance Date: 20/9/2018
Electronic publication date: 17/10/2018
Collection year: 2018

© 2018 Hornstrup et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the University Clinic of Nephrology and Hypertension, Holstebro Hospital, Aarhus University, Laegaardvej 12J, DK-7500 Holstebro, Denmark, Tel: 45 7843 6590; E-mail:

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