The Open Infectious Diseases Journal




ISSN: 1874-2793 ― Volume 10, 2018
SYSTEMATIC REVIEW

Varicella (Human Herpes Virus-3) Vaccine Potential Role Against Herpes (HSV-1/HSV-2) Viruses to Prevent HIV-1 Pandemic in Sub- Saharan Africa



Jacqueline Le Goaster1, *, Patrice Bourée1, Franck N. El Sissy1, Johanna Pokossy Epee1, Frédéric Tangy2, Anne-Lise Haenni3, Allan Goldstein4
1 Department of Tropical Diseases, Hôtel-Dieu, University Paris V, Paris, France
2 Viral Genomics, Vaccinations, CNRS, Pasteur Institute, Paris, France
3 Jacques Monod Institute, CNRS, University Paris VII, Paris, France
4 Department Biochemistry and Molecular Medicine, The George Washington University, Washington, DC 20037, USA

Abstract

Background:

Synergy exists between DNA and RNA viruses. It was found that the Human Immunodeficiency Viruses (HIV-1) are RNA viruses at the origin of Acquired Immune Deficiency Syndrome (AIDS). The DNA recurrent herpes diseases are associated to AIDS virus at the origin of Sub-Saharan cancer AIDS pandemic.

Objective:

It is speculated that a varicella virus (HHV-3) immune defect could originate HSV- 1/HSV-2 recurrent herpes diseases that can be cured by varicella vaccine (2012).

Methods:

At a Symposium held in Kampala, Uganda (1962), impressive Sub-Saharan cancer epidemics: Hodgkin lymphomas and Kaposi sarcomas have been reported since the onset of the 20th century and remained unexplained. Over one thousand publications related to these cancer epidemics were presented. For millenniums, Bantu populations have been living in tropical forests close to chimpanzees infected by Simian Immune Deficiency viruses (SIV). SIV became Human Immune Deficiency viruses (HIV-1). AIDS is a zoonosis.

Results:

The DNA and RNA viruses, herpes with HIV-1 viruses, are correlated to Sub- Saharan AIDS infections. They induce an extensive immune deficiency with other herpes viruses such as HHV-4 and HHV-8, which are linked to lymphomas and Kaposi sarcomas. It is postulated that a primary HHV-3 immune weakness could be linked to herpes partnership with AIDS pandemic.

Conclusion:

The Oka, anti-HHV-3, varicella vaccine is able to cure HSV1/HSV2 recurrent herpes diseases. It induces a specific increase of the varicella antibodies. Thus varicella vaccination could prevent herpes recurrences in Sub-Saharan Africa. One- child dose varicella vaccine could be proposed as the first step to overcome HHV-3 herpes deficiency in order to prevent AIDS pandemic.

Keywords: Varicella (HHV-3) vaccine, HSV-1/HSV-2/Herpes viruses/HIV-1, AIDS prevention, Sub-Tropical Africa, Hodgkin lymphomas, Kaposi sarcomas.


Article Information


Identifiers and Pagination:

Year: 2018
Volume: 10
First Page: 116
Last Page: 123
Publisher Id: TOIDJ-10-116
DOI: 10.2174/1874279301810010116

Article History:

Received Date: 31/5/2018
Revision Received Date: 27/7/2018
Acceptance Date: 6/8/2018
Electronic publication date: 31/08/2018
Collection year: 2018

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© 2018 Le Goaster et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Department of Tropical Diseases, Patrice Bouree Hotel Dieu, University Paris V, Paris, France; Tel: 00 33 1 45 03 11 35; E-mail: j.lego@free.fr


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