So far the allergen list of the International Union of Immunological Societies (IUIS) allergen nomenclature
subcommittee comprises 130 plant-derived food allergens. Based on sequence homology these allergens can be classified
into only 27 out of 9,000 known protein families according to the Allfam database. These families comprise the prolamin
and cupin superfamilies, pathogenesis related proteins, profilins, thaumatin-like proteins, oleosins, expansins, a number of
enzymes and protease inhibitors among others. The classification on structural and thus biochemical and functional similarities
will provide a new outlook on the molecules and might contribute to answer the question about allergenicity of different
proteins. This will help to define clinical relevant allergenic molecules and explain cross-reactive phenomena between
single food allergen sources as well as between food allergens and allergenic molecules of other origins (e.g. pollen).
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