Human γδ T cells appear to belong to non-classical T cells with both innate and adaptive immune features.
Vγ2Vδ2 (also termed Vγ9Vδ2) T cell subset exists only in primates, and in humans that represents a major γδ T cell
subpopulation in the blood. Vγ2Vδ2 T cells remain to be the only γδ T cell subpopulation that can recognize a welldefined
foreign microbial phosphoantigen. This article reviews the recent progress in our understanding immune
regulation of Vγ2Vδ2 T cells.