The resident population of γδ T cells in the normal lung is small but during lung inflammation, γδ T cells can
increase dramatically. Histological analysis reveals diverse interactions between γδ T cells and other pulmonary
leukocytes. Studies in animal models show that γδ T cells play a role in allergic lung inflammation where they can protect
normal lung function, that they also are capable of resolving infection-induced pulmonary inflammation, and that they can
help preventing pulmonary fibrosis. Lung inflammation threatens vital lung functions. Protection of the lung tissues and
their functions during inflammation is the net-effect of opposing influences of specialized subsets of γδ T cells as well as
interactions of these cells with other pulmonary leukocytes.