The Open Medicinal Chemistry Journal

ISSN: 1874-1045 ― Volume 13, 2019

Chronic Experimental Diabetes Accelerates Urinary Elimination of Deprenyl and its Metabolites

Ernest Adeghate*, 1, Péter Sótonyi, Jr2, Huba Kalász3, §
1 Department of Anatomy, Faculty of Medicine & Health Sciences, United Arab Emirates University, Al Ain, P.O. Box 17666, United Arab Emirates
2 Department of Cardiovascular Surgery, Semmelwies University, Budapest, Hungary
3 Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, P.O. Box 370, Hungary 1445


Many diabetic patients take several medications to treat diabetes-associated complications and other ailments. The mode of elimination of these drugs and their metabolites are poorly understood. The elimination of deprenyl, a MAO-B inhibitor, used for the treatment of the early stage of Parkinson’s disease and senile dementia was investigated using thin layer chromatography.

Male Wistar rats (180-200 g) were rendered diabetic by streptozotocin (STZ) treatment (60 mg/kg, i.v.). Rats having at least three times higher plasma glucose level than the normal were considered diabetic. Rats were treated with a single oral dose of 5 mg/kg 14C-(methyl)-labeled (-)-deprenyl, 98 (Ci/mg. Diabetic rats excreted the majority of urinary radioactivity in 8 hours, while control rats did it in 16 hours. The approximate ratio of major metabolites as determined using thin-layer chromatography did not change. In conclusion, diabetic rats excreted radiolabelled-deprenyl more rapidly compared to control animals. Increased elimination of deprenyl should be taken into account in the management of patients suffering from diabetes.

Keywords: Deprenyl, diabetes, pharmacokinetics, urinary elimination.

Article Information

Identifiers and Pagination:

Year: 2008
Volume: 2
First Page: 1
Last Page: 5
Publisher Id: TOMCJ-2-1
DOI: 10.2174/1874104500802010001

Article History:

Received Date: 3/12/2007
Revision Received Date: 26/12/2007
Acceptance Date: 27/12/2007
Electronic publication date: 10/1/2008
Collection year: 2008

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2008 Bentham Science Publishers Ltd.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.

* Address correspondence to this author at the Department of Anatomy, Faculty of Medicine & Health Sciences, United Arab Emirates University, Al Ain, P.O. Box 17666, United Arab Emirates Tel: +971-3-7672033 Fax: +971-3-7137496 E-mail:§ Present Address: Department of Pharmacology & Therapeutics, Faculty of Medicine & Health Sciences, United Arab Emirates University, Al Ain, P. O. Box 17666, United Arab Emirates


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