In this paper, a polynomial fitting improved Bayesian approach is proposed for the reconstruction of volumetric
metabolite images from long echo time (TE) whole brain proton magnetic resonance spectroscopic imaging (MRSI) data.
The proposed algorithm uses a modified EM (expectation maximization) algorithm that takes into account the partial volume
effects contained inside a thick slice MRSI. It incorporates high resolution volumetric magnetic resonance imaging
(MRI) as a priori information. It further integrates the polynomial fitting method to smooth out artificial edges before the
high resolution metabolite images are reconstructed. Our proposed reconstruction method has successfully extended our
existing reconstruction of two dimensional (2D) metabolite images to 3D cases. The experimental results show that resolution
enhanced volumetric metabolite images are reconstructed.