3 Pediatric Oncology Unit, Ospedale Vito Fazzi, Lecce, Italy
In children treated for brain tumors, important deficits in cognitive development have been described. The reduction of Intelligence Quotient (IQ) is correlated with multiple conditions such as tumor location, obstructive hydrocephalus, surgical intervention, and above all, the use of radiotherapy, especially in young children. Demyelinization represents the most striking microscopic alteration following radiation: cerebral white matter’s loss and failure to white matter development could partly account for changes in IQ score.
Recently, combined chemo-radiotherapeutic approaches and the improvement of radiotherapy techniques have enabled the reduction of neurocognitive symptoms and improved the standard of life of childhood brain tumor survivors.
Keywords: Children, Brain tumors, Neurocognitive deficit, Radiotherapy, IQ score, Young childrens, Radiation.
* Address correspondence to this author at the Paediatric Oncology Unit, Fondazione Policlinico Universitario A .Gemelli IRCCS, Largo A. Gemelli 8, 00168 Rome, Italy; Tel: +39 06 30155165; Fax: +39 06 3052751; E-mail: firstname.lastname@example.org