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This study was designed to examine the protective role of vitamin C (VC) against oxidative stress and
morphological changes induced by chronic exposure to cadmium chloride (CdCl2) in the lungs and brain. Male adult
rats received CdCl2 (5 mg/kg body weight) daily for forty days. Vitamin C (VC) at a dose of 100 mg/kg body weight
was given concomitantly with CdCl2 to the rats. Three animal groups were used in this experiment (control, CdCl2 and
CdCl2+VC). The concentration of malondialdehyde (MDA), activity of superoxide dismutase (SOD) enzyme and
concentration of glutathione (GSH) were measured in the lung and brain homogenates. Also, histopathological
investigations were carried out in lung and brain tissues. CdCl2 administration significantly increased the levels
of MDA and decreased the activity of SOD and GSH concentration in the lungs and brain versus those of control rats.
Administration of vitamin C counteract the changes of all measured parameters and appear nearly like those of controls.
Light microscopy revealed marked changes in the structure of the studied tissues of CdCl2 administered animals. Again,
vitamin C restored the damage of tissues associated with CdCl2 administration. The present results suggest that
vitamin C administration attenuated the oxidative damage and morphological changes induced by CdCl2 in the lungs and
brain of rats.