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Hyperthermia induces vasodilatation that reduces central blood volume (CBV), central venous
pressure (CVP) and mean arterial pressure (MAP). Inhibition of atrial natriuretic peptide (ANP) could be a relevant
homeostatic defense mechanism during hyperthermia with a decrease in CBV. The present study evaluated how changes
in plasma ANP reflect the changes in CBV during hyperthermia.
Ten healthy subjects provided with a water perfused body suit increased body core temperature 1 °C. In situ
labeled autologous red blood cells were used to measure the CBV with a gamma camera. Regions of interest were traced
manually on the images of the whole body blood pool scans. Two measures of CBV were used: Heart/whole body ratio
and thorax/whole body ratio. CVP and MAP were recorded. Arterial (ANPart) and venous plasma ANP were determined
The ratio thorax/whole body and heart/whole body decreased 7 % and 11 %, respectively (p<0.001). MAP and
CVP decreased during hyperthermia by 6.8 and 5.0 mmHg, respectively (p<0.05; p<0.001). Changes in both thorax/whole
body (R=0.80; p<0.01) and heart/whole body ratios (R=0.78; p<0.01) were correlated with changes in ANPart. However,
there was no correlation between venous ANP and changes in CBV, nor between ANPart and MAP or CVP.
Arterial but not venous plasma concentration of ANP, is correlated to changes in CBV, but not to pressures.
We suggest that plasma ANPart may be used as a surrogate marker of acute CBV changes.