Internal Carotid Artery (ICA) stenosis is a common condition with a high prevalence
in the normal population and carries a high risk of stroke. Hemodynamic impairment has been proven to be a powerful
and independent risk factor for stroke. Understanding the hemodynamics beyond a stenosis may play a role in selecting
patients who would benefit from treatment, determining the success of the treatment, and monitoring for disease recurrence.
Our group has developed a unique quantitative approach to MR perfusion. We report on the use of Quantitative
Magnetic Resonance Perfusion (MRP) for assessment of Cerebral Blood Flow (CBF) pre- and post- Carotid Angioplasty
and Stenting for symptomatic ICA stenosis.
A 71-year-old female with significant comorbidities presented with two episodes of left transient
ischemic attacks (TIAs) over the course of one month related to high grade left ICA stenosis. Preoperative quantitative
MRP showed asymmetry in CBF between the two hemispheres. Carotid angioplasty and stenting was recommended.
Left ICA angioplasty and stenting was performed and reduced the stenosis to <10%. Quantitative MRP done
after the procedure revealed improved CBF to the affected side and normalization in the asymmetry of perfusion between
the two hemispheres. Quantitative MRP values showed that affected regions were hypoperfused, but flow was sufficiently
maintained so as to avoid infarct.
Relative MRP images allowed us to elucidate improvement in perfusion resulting form carotid angioplasty
and stenting. This novel quantitative MRP allows quantification of CBF and the potential to provide additional information
on the degree of hemodynamic compromise.