In the present investigation, we have studied the bronchoprotective effect of ethanolic extract of Achyranthes apsera Linn. in toluene diisocyanate (TDI) induced occupational asthma in wistar rats. Wistar rats were divided into four
different groups of eight animals each. All animals except control group were sensitized by the intranasal application of
10% TDI to induce airway hypersensitivity. At the end of the study, after provocation with 5%TDI the symptoms were
observed in all animals. The total and differential leucocytes were counted in blood and bronchoalveolar (BAL) fluid.
Liver homogenate was utilized for assessment of oxidative stress and lung histological examination was performed to investigate
the inflammatory status in the airway. TDI sensitized rats exhibited asthmatic symptoms while A. aspera and
dexamethasone treated rats did not show any airway abnormality. The neutrophils and eosinophils in blood were decreased
significantly; the total cells and each different cell in particular eosinophils in BAL fluid were markedly decreased
in treatment groups as compared to TDI sensitized rats. The antioxidant activity and histopathological observations also
showed protective effect. From all above findings and observations, it can be concluded that A. aspera has beneficial role
in occupational asthma.