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Lapachol whose isolation and study at the end of the century by Parternó, is one of the most brilliant chapters
of Phytochemistry, especially in conjunction with the work of Max Siewert a communication on the wood of the Argentina
Lapachol (Bignoniaceae) tree from Max Siewert, submitted along with Ricardo Napp in Exp. NAC. Philadelphia in
1876. The Lapachol has its origin in the Tabebuia avellanedae Lorentz ex. Griseb (Bignoniaceae) which in Brazil is
known as Pau D′Arc, Ipê-purple, Ipê-Black, and Yellow-Ipê. It is a tree of huge size used in traditional medicine for cases
of stomatitis, inflammatory processes in general and against cancer. β-Lapachone is an o-naphthoquinone from Lapachol
used against, Trypanosome cruzi, cancer, viruses, bacteria, and leishmania is currently evaluated. This plant can also be
found in other plant families such as, Verbenaceae Leguminosae, Sapotaceae, Scrophulariaceae, Malvaceae and Proteaceae.
This paper aims at demonstrating the pharmacology and clinical activity of Lapachol and β-Lapachone, through
their mechanism of action, and other actions which are not related to their anti neoplastic activity.