This 8-week, open-label study evaluated the effects of a specialized whey protein supplement (OsoLean™
powder), rich in bioactive peptides and calcium, on weight loss in a convenience sample of healthy, overweight adults.
Participants were advised to restrict their daily caloric intake and instructed to add the supplement to the beverage of their
choice before breakfast and dinner. Subjects were provided a tracking log in which they were asked to record their height,
daily supplement consumption, and weekly self-measurements of weight, waist circumference, and estimated daily caloric
intake. BMI was calculated by the study coordinator using the self-reported height and weight measurements. Out of 112
enrolled subjects, 110 completed the first 4-week study period and 68 continued to complete the second 4 weeks. Subjects
reported an average ±standard error (SE) weight loss of 2.0±0.2 kg by week 4 (p<0.0001) and 2.8±0.3 kg by week 8
(p<0.0001). Mean BMI values were significantly decreased after 4 and 8 weeks, by 0.7±0.1 and 1.0±0.1 points, respectively.
Average centimeters lost from the waist was 5.1±0.3 cm at week 4 (p<0.0001) and 7.1±0.7 cm at week 8
(p<0.0001). Subjects completing quality of life questionnaires reported better appetite control and improved energy levels
by the end of the study. These preliminary results suggest that supplementation with this specialized whey protein product
may result in significant weight loss and appetite control in overweight consumers. However, because of this study’s uncontrolled,
open-label methodology, cause-and-effect inferences can only be confirmed when a double-blind, randomized
placebo-controlled trial is performed.
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