Abstract HTML Views: 291 PDF Downloads: 214 Total Views/Downloads: 505
Abstract HTML Views: 220 PDF Downloads: 169 Total Views/Downloads: 389
Intensive research over recent years has provided irrefutable evidence of links between obesity and the risk of
an increasing number of human cancers. The predicted economic burden is causing significant concern. This has
prompted investigation of the underlying mechanisms with a focus on deregulated metabolic pathways. A number of
metabolic processes and associated signalling pathways are associated with the development of obesity. These include a
number of interlinking pathways regulating endocrine, redox, inflammation, immunity and lipogenic processes. The
identification of deregulated metabolic pathways in obesity with promotion of carcinogenesis has targeted research on the
signalling molecules involved. Consequently this mini review is focused on aberrant signalling of deregulated pathways
provoked by diets that lead to obesity and their role in carcinogenesis. Knowledge of the signalling molecules involved
will assist in directing and establishing dietary manipulation strategies to restore metabolic health in obese individuals.
Importantly the identified diversity of signalling pathways linked to obesity related cancers will permit design of more
effective combinatorial and multi-targeted cancer therapies in the future.