A new set of branched high-molecular weight multifunctional poly(ethylene glycol) (MultiPEG) derivatives
was obtained from smaller commercial diOH-PEGs (M.W. = 2000 and 6000 Da) which were selectively monoprotected,
properly activated at the residual OH-functions and treated with 1,3-diamino-2-propanol and 2-amino-1,3-propandiol as
polyfunctional linkers. They were purified by molecular exclusion chromatography or extensive dialysis and characterized
by GPC and 1H-NMR. The final polymeric derivatives are characterized by a higher number of terminal reacting moieties
(up to 6 times) than that found in linear, commercial PEGs of same molecular size. This increased loading capability can
be applied to improve their use as drug carriers and soluble synthetic supports.